Endocrine Abstracts

The aim of this work was to study the condition of the reproductive system after long-term administration of letrozole followed by its withdrawal in young males and against the background of involutive changes in aging males in a comparative aspect. The experiments were carried out on Wistar rats with an initial age of 5 months and 15 months, which have been gavaged by letrozole every other day at a dose of 1 mg/kg body weight for 3 months and then 2 months after its discontin...

One of the most common environmental endocrine disruptor is bisphenol A (BPA), which mimics estrogen effects. Even at low expositional dose, BPA is capable of transferring across the human placenta in active unconjugated form. The purpose of this work was to investigate the long-term effects of low dose BPA introduction to rats during the critical period of sexual differentiation of the brain on the reproductive system and the behavior of F1 offspring. Wistar dams were exposed...

Adolescence is one of the most dynamic periods of development, which is highly sensitive to changes induced by stressors. Disruption in hormonal balance associated with stress have a negative impact on puberty and reproductive function. The aim of the work was to study the long-term endocrine effects of chronic pubertal stress in rats. On the 22 postnatal day (PND), the Wistar rats were separated from their mothers and sorted by sex into individual cages, so that animals from ...